Department of Anesthesia, Nippon Medical School Chiba Hokusoh Hospital, Chiba, Japan; Department of Anesthesiology, Nippon Medical School Hospital, Tokyo, Japan <\/p>\n

Address correspondence and reprint requests to Toshiya Shiga, MD, PhD, Department of Anesthesia, Nippon Medical School Chiba Hokusoh Hospital, Kamagari 1715, Inba-mura, Inba-gun, Chiba 270\u20131694, Japan. Address e-mail to qzx02115@nifty.com.<\/p>\n

Aprotinin therapy is a promising strategy for reducing blood loss and blood transfusion requirements. The efficacy and safety of aprotinin in orthopedic surgery, however, remain controversial. We searched electronic databases for randomized controlled trials on the efficacy and safety of the use of aprotinin in orthopedic surgery. Thirteen trials that included a total of 506 patients who underwent major orthopedic surgery were analyzed. The pooled intraoperative and perioperative blood loss was significantly less in the aprotinin-treated patients than in the control patients (weighted mean difference [WMD] for intraoperative blood loss = \u2013229 mL, 95% confidence interval [CI] = \u2013367 to \u201391 mL, P = 0.0011; WMD for perioperative blood loss = \u2013557 mL; 95% CI = \u2013860 to \u2013254 mL; P < 0.0001). The pooled amounts of red blood cell (RBC) units (U) transfused intraoperatively and perioperatively were significantly less in the aprotinin-treated patients than in the control patients (WMD for intraoperative RBC U = \u20131.1 U; 95% CI = \u20131.7 to \u20130.4 U; P = 0.0001; WMD for perioperative RBC U = \u20131.1 U; 95% CI = \u20131.7 to \u20130.5 U; P < 0.0001). Aprotinin was not associated with an increased incidence of deep vein thrombosis (odds ratio = 0.39; 95% CI = 0.14 to 1.05, P = 0.061). The authors conclude that aprotinin reduces the intraoperative and perioperative blood loss and allogeneic blood transfusion requirement and may not be associated with increased risk of deep vein thrombosis in the presence of pharmacological or mechanical prophylaxis in patients undergoing major orthopedic surgery.\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Editorial: Anesth Analg Fecha: 01\/11\/2005 Toshiya Shiga, Zen’ichiro Wajima, Tetsuo Inoue, and Atsuhiro Sakamoto Acceso al enlace publicador Department of<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[4],"tags":[],"_links":{"self":[{"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/posts\/118"}],"collection":[{"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/comments?post=118"}],"version-history":[{"count":1,"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/posts\/118\/revisions"}],"predecessor-version":[{"id":904,"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/posts\/118\/revisions\/904"}],"wp:attachment":[{"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/media?parent=118"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/categories?post=118"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/tags?post=118"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}