{"id":150,"date":"2006-01-01T00:00:01","date_gmt":"2006-01-01T00:00:01","guid":{"rendered":"https:\/\/awge.doctime.es\/?p=150"},"modified":"2016-05-24T08:24:49","modified_gmt":"2016-05-24T06:24:49","slug":"awge-282","status":"publish","type":"post","link":"https:\/\/awge.doctime.es\/index.php\/2006\/01\/01\/awge-282\/","title":{"rendered":"Intravenous iron and recombinant erythropoietin for the treatment of postoperative anemia. 2006; 53: 11-9. –"},"content":{"rendered":"

Can J Anesth
\nKarkouti K, McCluskey SA, Ghannam M, Salpeter MJ, Quirt I, Yau TM.
\nAcceso al enlace publicador<\/a><\/p>\n

To determine if early recovery from severe post-operative anemia is accelerated by iv iron therapy alone or in combination with recombinant erythropoietin (EPO). METHODS: In this double-blinded, placebo-controlled randomized study, consenting adult patients without preoperative anemia whose hemoglobin concentration (Hb) was 70 to 90 g x L(-1) on the first day after cardiac or orthopedic surgery (POD 1) were assigned to one of three groups: control, iv iron alone (200 mg of iron sucrose on POD 1, 2, and 3) or in combination with EPO (600 U x kg(-1) on POD 1 and 3). The primary outcome was increase in Hb (adjusted for red blood cell transfusions) from POD 1 to 7. Analysis was by intention-to-treat in patients for whom the primary outcome was available. Group effect was analyzed by the ANOVA test, and between-group differences were specified with a Duncan multiple-range test. RESULTS: The primary outcome was available in 31 of 38 randomized patients. The average POD 1 Hb was 84 +\/- 4 g x L(-1). There were no between-group differences in outcomes except for higher reticulocyte counts on POD-7 in the combination group. The average adjusted one-week increases in Hb were 7 +\/- 8 g x L(-1) in the control group (n = 10), 9 +\/- 9 g x L(-1) in the iv iron group (n = 11), and 10 +\/- 14 g x L(-1) in the combination group (n = 10). The average adjusted six-week increases in Hb were 37 +\/- 14 g x L(-1) in the control group, 40 +\/- 7 g x L(-1) in the iv iron group, and 45 +\/- 12 g x L(-1) in the combination group. CONCLUSION: Early postoperative treatment with iv iron alone or in combination with EPO does not appear to accelerate early recovery from postoperative anemia.<\/p>\n","protected":false},"excerpt":{"rendered":"