Background: Transfusion has long been identified as a risk factor for acute lung injury\/acute respiratory distress syndrome (ALI\/ARDS). No study has formally evaluated transfusion of specific blood products as a risk factor for ALI\/ARDS in critically ill medical patients. Method In this single center retrospective cohort study, 841 consecutive critically ill patients were studied for the development of ALI\/ARDS. Patients who received blood product transfusions were compared with those who did not, in univariate and multivariate analyses. Results Two hundred ninety eight patients (35%) received blood transfusion. Transfused patients were older (67+\/-17 vs 62+\/-19 years, p<0.001) and had higher acute physiologic and chronic health evaluation (APACHE) III scores (74+\/-32 vs 58+\/-23, p<0.001). ALI\/ARDS (25% vs 18%, p= 0.025) developed more commonly in patients exposed to transfusion. Seventeen patients received massive (>10) red blood cell (RBC) transfusions, of whom 13 also received fresh frozen plasma (FFP) and 11 received platelet transfusion. When adjusted for probability of transfusion and other ALI\/ARDS risk factors, any transfusion was associated with development of ALI\/ARDS (OR 2.14, 95% CI 1.24 to 3.75). Amongst the individual blood products, recipients of FFP (OR 2.48, 95% CI 1.29 to 4.74) and platelets (OR 3.89 95% CI 1.36 to 11.52) were more likely to develop ALI\/ARDS than patients who received only RBC (OR 1.39, 95%CI 0.79 to 2.43) transfusions. Conclusion Transfusion is associated with increased risk of developing ALI\/ARDS in critically ill medical patients. The risk is higher with plasma rich blood products, FFP and platelets, than with RBC transfusions.<\/div>\n","protected":false},"excerpt":{"rendered":"

Editorial: Chest Fecha: 01\/03\/2007 Khan H, Belsher J, Yilmaz M, Afessa B, Moore SB, Hubmayr RD, Gajic O. Acceso al<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[4],"tags":[],"_links":{"self":[{"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/posts\/217"}],"collection":[{"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/comments?post=217"}],"version-history":[{"count":1,"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/posts\/217\/revisions"}],"predecessor-version":[{"id":821,"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/posts\/217\/revisions\/821"}],"wp:attachment":[{"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/media?parent=217"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/categories?post=217"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/tags?post=217"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}