OBJECTIVE: To test the hypothesis that RBC transfusion in critically ill children is independently associated with increased mortality and morbidity. DESIGN: Retrospective, descriptive epidemiologic cohort study. SETTING: Single-center experience of a nine-bed pediatric intensive care unit (PICU) facility. PATIENTS: Critically ill children without ongoing active blood loss aged 0[Symbol: see text]months to 18[Symbol: see text]years, excluding prematurely born infants or patients after cardiothoracic surgery, and patients with chronic anemia. INTERVENTIONS: None. MEASUREMENTS AND RESULTS: Data of 295 consecutive patients was studied. Of these patients, 13.4% had a Hb concentration less than 9.6[Symbol: see text]g\/dl. Sixty-seven (22.7%) of all patients were transfused, 39 only once. Transfused patients had a higher mortality (16.4 vs. 2.6%, p[Symbol: see text]<[Symbol: see text]0.001). Mortality seemed related to the number of transfusion (p[Symbol: see text]=[Symbol: see text]0.002) rather than the pre-transfusion Hb concentration (p[Symbol: see text]=[Symbol: see text]0.10). Transfused patients required prolonged ventilatory support (11.1[Symbol: see text]+\/-[Symbol: see text]1.8 vs. 3.2[Symbol: see text]+\/-[Symbol: see text]0.3[Symbol: see text]days, p[Symbol: see text]<[Symbol: see text]0.001), infusion of vaso-active agents (8.2[Symbol: see text]+\/-[Symbol: see text]1.8 vs. 2.8[Symbol: see text]+\/-[Symbol: see text]0.6[Symbol: see text]days, p[Symbol: see text]<[Symbol: see text]0.001) and PICU stay (13.0[Symbol: see text]+\/-[Symbol: see text]1.8 vs. 3.2[Symbol: see text]+\/-[Symbol: see text]0.2[Symbol: see text]days, p[Symbol: see text]<[Symbol: see text]0.001). After multivariate analysis adjusting for age, PIM probability of death, mean TISS-28 score during the first 48[Symbol: see text]h, post-operative admission, diagnosis of sepsis or trauma or malignancy, pre-transfusion Hb concentration, and RBC transfusion remained independently associated with mortality and morbidity. CONCLUSIONS: RBC transfusion in critically ill children is independently associated with increased mortality and prolonged duration of mechanical ventilation, prolonged infusion of vaso-active agents and prolonged PICU stay\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Editorial: Intensive Care Med Fecha: 01\/06\/2007 Kneyber MC, Hersi MI, Twisk JW, Markhorst DG, Pl\u00f6tz FB. Acceso al enlace publicador<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[4],"tags":[],"_links":{"self":[{"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/posts\/229"}],"collection":[{"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/comments?post=229"}],"version-history":[{"count":1,"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/posts\/229\/revisions"}],"predecessor-version":[{"id":806,"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/posts\/229\/revisions\/806"}],"wp:attachment":[{"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/media?parent=229"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/categories?post=229"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/tags?post=229"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}