Summary
\nBackground Preoperative anaemia is associated with adverse outcomes after cardiac surgery but outcomes after
\nnon-cardiac surgery are not well established. We aimed to assess the eff ect of preoperative anaemia on 30-day
\npostoperative morbidity and mortality in patients undergoing major non-cardiac surgery.
\nMethods We analysed data for patients undergoing major non-cardiac surgery in 2008 from The American College of
\nSurgeons\u00a1\u00af National Surgical Quality Improvement Program database (a prospective validated outcomes registry from
\n211 hospitals worldwide in 2008). We obtained anonymised data for 30-day mortality and morbidity (cardiac,
\nrespiratory, CNS, urinary tract, wound, sepsis, and venous thromboembolism outcomes), demographics, and
\npreoperative and perioperative risk factors. We used multivariate logistic regression to assess the adjusted and
\nmodifi ed (nine predefi ned risk factor subgroups) eff ect of anaemia, which was defi ned as mild (haematocrit
\nconcentration >29\u00a8C<39% in men and >29\u00a8C<36% in women) or moderate-to-severe (\u00a1\u00dc29% in men and women) on\npostoperative outcomes.\nFindings We obtained data for 227 425 patients, of whom 69 229 (30\u00a1\u00a444%) had preoperative anaemia. After adjustment,\npostoperative mortality at 30 days was higher in patients with anaemia than in those without anaemia (odds ratio [OR]\n1\u00a1\u00a442, 95% CI 1\u00a1\u00a431\u00a8C1\u00a1\u00a454); this diff erence was consistent in mild anaemia (1\u00a1\u00a441, 1\u00a1\u00a430\u00a8C1\u00a1\u00a453) and moderate-to-severe\nanaemia (1\u00a1\u00a444, 1\u00a1\u00a429\u00a8C1\u00a1\u00a460). Composite postoperative morbidity at 30 days was also higher in patients with anaemia\nthan in those without anaemia (adjusted OR 1\u00a1\u00a435, 1\u00a1\u00a430\u00a8C1\u00a1\u00a440), again consistent in patients with mild anaemia (1\u00a1\u00a431,\n1\u00a1\u00a426\u00a8C1\u00a1\u00a436) and moderate-to-severe anaemia (1\u00a1\u00a456, 1\u00a1\u00a447\u00a8C1\u00a1\u00a466). When compared with patients without anaemia or a\ndefi ned risk factor, patients with anaemia and most risk factors had a higher adjusted OR for 30-day mortality and\nmorbidity than did patients with either anaemia or the risk factor alone.\nInterpretation Preoperative anaemia, even to a mild degree, is independently associated with an increased risk of\n30-day morbidity and mortality in patients undergoing major non-cardiac surgery.<\/div>\n","protected":false},"excerpt":{"rendered":"

Editorial: Lancet Fecha: 01\/11\/2011 Khaled M Musallam, Hani M Tamim, Toby Richards, Donat R Spahn, Frits R Rosendaal, Aida Habbal,<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[4],"tags":[],"_links":{"self":[{"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/posts\/418"}],"collection":[{"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/comments?post=418"}],"version-history":[{"count":1,"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/posts\/418\/revisions"}],"predecessor-version":[{"id":667,"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/posts\/418\/revisions\/667"}],"wp:attachment":[{"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/media?parent=418"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/categories?post=418"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/tags?post=418"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}