{"id":435,"date":"2012-12-01T00:00:01","date_gmt":"2012-12-01T00:00:01","guid":{"rendered":"https:\/\/awge.doctime.es\/?p=435"},"modified":"2016-05-24T08:00:41","modified_gmt":"2016-05-24T06:00:41","slug":"awge-3","status":"publish","type":"post","link":"https:\/\/awge.doctime.es\/index.php\/2012\/12\/01\/awge-3\/","title":{"rendered":"Pathophysiology of perioperative anaemia"},"content":{"rendered":"<div class=\"editorialPost\"><strong>Editorial: Best Practice<\/strong><\/div>\n<div class=\"fechaPost\">Fecha: 01\/12\/2012<\/div>\n<div class=\"autorPost\">Sumit Singh, MD, , Vadim Gudzenko, MD, Mitchell P. Fink<\/div>\n<div class=\"enlacePost\"><a target=\"_blank\">Acceso al enlace publicador<\/a><\/div>\n<hr \/>\n<div class=\"resumenPost\">Perioperative anaemia is a common clinical entity. It is usually due<br \/>\nto combination of various mechanisms, including: pre-existing<br \/>\nanaemia prior to surgery; anaemia due to impaired erythropoiesis,<br \/>\nincluding alterations of metabolism of iron and erythropoietin<br \/>\n(EPO); anaemia due to increased destruction of red blood cells<br \/>\n(RBCs); and anaemia due to iatrogenic causes. Postoperatively,<br \/>\nanaemia resembles anaemia of chronic disease and is probably<br \/>\nrelated to the effects of inflammatory mediators released during<br \/>\nand after surgery on the production and survival of RBCs. Proinflammatory<br \/>\ncytokines, such as tumour necrosis factor, impair<br \/>\nerythropoietin-dependent signalling and iron homeostasis. Iatrogenic<br \/>\ncauses, notably excessive phlebotomies, remain a major<br \/>\ncause of perioperative anaemia. With increasing emphasis on<br \/>\nrestrictive blood transfusion strategies, understanding these<br \/>\nmechanisms is important for the clinician.<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Editorial: Best Practice Fecha: 01\/12\/2012 Sumit Singh, MD, , Vadim Gudzenko, MD, Mitchell P. Fink Acceso al enlace publicador Perioperative<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[],"_links":{"self":[{"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/posts\/435"}],"collection":[{"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/comments?post=435"}],"version-history":[{"count":1,"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/posts\/435\/revisions"}],"predecessor-version":[{"id":618,"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/posts\/435\/revisions\/618"}],"wp:attachment":[{"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/media?parent=435"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/categories?post=435"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/awge.doctime.es\/index.php\/wp-json\/wp\/v2\/tags?post=435"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}