The role of intravenous iron in anemia management and transfusion avoidance.
Editorial: Transfusion
Fecha: 01/05/2008
Auerbach M, Goodnough LT, Picard D, Maniatis A.
Parenteral iron preparations available in the past
were associated with a risk of anaphylaxis and
death, which made physicians reluctant to use
them. The formulation most frequently responsible
for these serious adverse events is high-molecularweight
iron dextran (HMW ID). The availability, first in
Europe and more recently in the USA, of three other
preparations (low-molecular-weight [LMW] ID, iron
sucrose, and ferric gluconate), with a much better safety
profile, is changing the pattern of use, thus prompting this
review of paradigms of anemia correction by intravenous
(IV) iron administration, with an emphasis on transfusion
avoidance…
were associated with a risk of anaphylaxis and
death, which made physicians reluctant to use
them. The formulation most frequently responsible
for these serious adverse events is high-molecularweight
iron dextran (HMW ID). The availability, first in
Europe and more recently in the USA, of three other
preparations (low-molecular-weight [LMW] ID, iron
sucrose, and ferric gluconate), with a much better safety
profile, is changing the pattern of use, thus prompting this
review of paradigms of anemia correction by intravenous
(IV) iron administration, with an emphasis on transfusion
avoidance…